Mary Lou Henchy is a prostitute who worked at Head in the Clouds. She was hired by Laurens Bancroft alongside Lena Rentang to fulfil his sexual desires to choke out women. As part of a plot by Reileen Kawahara, Bancroft was dosed with Stallion by Miriam Bancroft. Bancroft real-deathed Lena, and Mary Lou ran to avoid being killed. She jumped off Head in the Clouds, believing that she would be spun back up and could testify against Bancroft. However, Reileen had secretly recoded Mary Lou's Cortical Stack to classify her as Neo-Catholic, meaning she could not be re-sleeved or spun back up.

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